MAMMOGENIC ACTIVITIES OF THE MID-GESTAT1ONAL MOUSE PLACENTA1

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Abstract
Two-month old virgin C3H mice were injected daily for 8 days in the right inguinal mammary area with an extract of fetal placentae from mice, 12 days pregnant. Mice receiving doses equivalent to 1, 2, or 3 placentae showed lobuloalveolar development on both sides, but more extensive growth on the injected side in all cases. The responses to a dose equivalent to half of a placenta indicated that this approximates the minimal effective mammogenic dosage. Corpora lutea were maintained, and vaginal cycles stopped in the mucification phase in the mice showing lobulo-aveolar mammary growth.