Apo2L/TRAIL is an indirect mediator of apoptosis induced by interferon‐α in human myeloma cells
- 17 October 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (27) , 6217-6222
- https://doi.org/10.1016/j.febslet.2005.10.007
Abstract
Interferon-α (IFN-α) is currently used for the therapy of multiple myeloma (MM) though it is only effective in some patients. IFN-α induces apoptosis in some MM cell lines and it has been proposed to occur through an autocrine loop involving Apo2L/TRAIL. We have analysed the sensitivity to IFN-α and Apo2L/TRAIL of five MM cell lines and found no correlation between the apoptosis inducing ability of both cytokines. IFN-α-induced apoptosis in MM cells was not prevented by a caspase-8 selective inhibitor (Z-IETD-fmk) or blocking Apo2L/TRAIL. However, human monocytes treated with IFN-α release bioactive Apo2L/TRAIL to culture media which was cytotoxic for MM cells resistant to IFN-α. We propose that Apo2L/TRAIL released from IFN-α-stimulated blood monocytes would be a major mediator of the anti-myeloma effect of IFN-α in vivoKeywords
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