EFFECT OF NEPHRECTOMY IN THE EVISCERATED RAT UPON TOLERANCE FOR INTRAVENOUSLY ADMINISTERED GLUCOSE

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Abstract
Male rats (185-205 g.) were caused to develop a collateral circulation by liga-tion of the inferior vena cava. At a wt. of 250 ([plus or minus]2) g. the animals were anesthetized (cyclopal) and eviscerated. The kidneys were removed from one animal of each pair. Infusions into the saphenous vein were made by continuous injection machines which delivered fluid at the rate of 20 ml. in 24 hrs. per rat. The level of blood glucose at the end of the injn. period was the index of glucose tolerance. In expt. 1,11 groups of eviscerated rats having 12 pairs of rats in each group were infused with glucose for 2 hrs. One rat of each pair was ne-phrectomized. At each glucose load with and without insulin the avg. level of blood glucose was significantly lower in the nephrectomized than in the non-nephrectomized animals. In expt. 2, 9 groups of eviscerated rats having 12 pairs of animals in each group were infused with glucose for a period of 24 hrs. In the groups without insulin and in those with an insulin dose of 0.5 units per 24 hrs. per rat, the avg. terminal level of blood glucose was lower in the nephrectomized-eviscerated than in the non-nephrectomized rats. At the higher levels of insulin dosage and glucose loads the order of tolerance was reversed and the nephrectomized animals had higher average terminal values for blood glucose than the non-nephrectomized rats.

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