Anaplasma phagocytophilumInfection Induces Protracted Neutrophil Degranulation
Open Access
- 1 June 2004
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (6) , 3680-3683
- https://doi.org/10.1128/iai.72.6.3680-3683.2004
Abstract
Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.Keywords
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