Nuclear Magnetic Resonance Studies of Cancer. V. Appearance and Development of a Tumor Systemic Effect in Serum and Tissues 2

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Abstract
Nuclear magnetic resonance spin-lattice relaxation times (T1) were elevated in the serum and certain tissues from tumor-bearing rodents when compared to control animals not given injections. Mice bearing lymphosarcoma 6C3HED and rats given injections of Morris hepatoma 3924A, a fast-growing, poorly differentiated tumor, were studied. In a time course study using Morris hepatoma 3924A, increases in both T1 and H20 content were observed in serum and tissues. A statistical analysis of variance over the course of the experiment showed that increases in these parameters in serum were greater than could be accounted for by day-to-day variability of the samples at 29 days post injection and after. Increases in liver, kidneys, and spleen exceeded daily sample variability only at 40 and 46 days post injection; increases in heart appeared in the statistical computations at day 46. Sample variability was too large to document any effect in skeletal muscle. The increases in T1 in serum, liver, kidneys, spleen, and heart were accompanied by an increase in the hydration of these samples in the direction predicted earlier. These increases, except possibly those in the spleen, became statistically significant above the level of ordinary sample variability during the same time period for both parameters in a given tissue. The results are discussed in terms of error inherent in the experimental procedure, relationship of tumor size, and possible mechanistic interpretation.

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