Humanized anti-CD20 monoclonal antibody in the treatment of severe resistant systemic lupus erythematosus in a patient with antibodies against rituximab
Open Access
- 11 January 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 44 (4) , 561-562
- https://doi.org/10.1093/rheumatology/keh533
Abstract
Sir, We present, to the best of our knowledge, the first case of a patient with severe resistant systemic lupus erythematosus (SLE) including the development of human antichimeric antibodies (HACA) after rituximab, who responded both clinically and serologically to an investigational humanized anti-CD20 monoclonal antibody (hA20) provided on a compassionate use basis by Immunomedics, Inc. (Morris Plains, NJ, USA).Keywords
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