EFFECT OF LOCAL ANESTHETICS ON REGENERATION OF CORNEAL EPITHELIUM
- 1 January 1944
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 31 (1) , 29-33
- https://doi.org/10.1001/archopht.1944.00890010047004
Abstract
Our purpose in the present investigation was to determine experimentally the effect of various local anesthetics on the regeneration of corneal epithelium. Clinically it has been observed from time to time that local anesthetics have an inhibitory influence on the regeneration of corneal epithelium. In 1902 Fuchs,1 for this reason, stated that patients should be prohibited from using cocaine at home for the treatment of corneal abrasions. Many of the newer anesthetics are, however, said to be innocuous. Stallard2 stated that tetracaine has no toxic effect on the regenerating epithelium. According to Gifford,3 0.5 per cent butacaine sulfate or phenacaine hydrochloride causes little or no damage to the epithelium and may be used several times a day. Heretofore no attempt has been made to determine experimentally whether or not local anesthetics affect the regrowth of corneal epithelium. METHOD Guinea pigs (4 for the study of each drug)Keywords
This publication has 0 references indexed in Scilit: