Second transplantation with CD34+ bone marrow cells selected from a two‐loci HLA‐mismatched sibling for a patient with chronic myeloid leukaemia
- 1 July 1996
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 94 (1) , 123-125
- https://doi.org/10.1046/j.1365-2141.1996.d01-1763.x
Abstract
A 43‐year‐old man with chronic myeloid leukaemia underwent a second transplant with CD34+ bone marrow cells selected from his two‐loci HLA‐mismatched sibling after rejection of the first graft from an HLA‐matched unrelated donor. By immunomagnetic positive selection, CD34+ marrow cells at 0.95×106/kg with 97% purity and CD3+ T lymphocytes at 1.3×104/kg were collected and transplanted. Engraftment was confirmed to be of CD34+ cell‐donor origin. The patient developed only grade I acute graft‐versus‐host disease (GVHD) and no chronic GVHD to date. These observations suggest that allogeneic CD34+ bone marrow cells are capable of reconstituting haemopoiesis and that CD34+ selection could be applicable to T‐cell depletion.Keywords
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