UREMIA DUE TO RENAL LYMPHOMATOSIS

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Abstract
A case of uremia following extensive bilateral diffuse infiltration of the kidney by lymphoblastic lymphoma in a 68 year old woman is presented. It is felt that primary lymphoma of the kidney probably never occurs. It has been noted that despite overwhelming involvement by lymphoma the functions of the kidney are rarely seriously comprised therapy. Thus uremia is rare. The patient had no signs of renal stones or of hydro or pyonephrosis which would have added to the retention of nitrogenous wastes. Though both spleen and liver are commonly seats of lesions in malignant lymphoma, this patient''s liver and spleen were free of tumor at autopsy. The patient came out of coma and became totally rational under prednisolone therapy. This was a dramatic but short term symptomatic improvement, in keeping with the literature, in which remissions of lymphoma with steroids were definite but brief. There was no improvement in renal function with steroids. It is of definite value to think of this diagnosis since the patient''s general disease and renal status may be improved by appropriate roentgen and chemotherapy.
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