IMMUNOSTAINING OF COLORECTAL-CANCER WITH MONOCLONAL ANTI-CEA ANTIBODIES COMPARED TO SERUM AND TUMOR CEA CONTENT

  • 1 September 1986
    • journal article
    • research article
    • Vol. 6  (5) , 893-896
Abstract
Carcinoembryonic antigen was measured in serum and in extracts from 37 colorectal tumors and we found a poor correlation between circulating and tumor CEA. Monoclonal antiCEA antibodies were used in indirect immunoperoxidase staining of the corresponding formalin fixed tissue sections. We found that serum CEA measurement had a sensitivity of only 41.9% as compared to 90.3% for the immunohistochemical staining. The positive and negative predictive values for immunostaining were respectively 96.6% and 72.7%. Immunohistochemical staining of tissue sections with monoclonal antiCEA coupled to other biochemical or immunological assays could be a useful adjunct for the diagnosis of premalignant or slightly modified tissues.