An Analog Computer Simulation for the Distribution of d-Tubocurarine

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Abstract
A nine compartment analog computer model was constructed to simulate and study the uptake and distribution of d-tubocurarine. By varying model parameters, six compartments were simulated using directly obtained experimental data. Drug distribution in the experimentally inaccessible compartments was obtained indirectly from the analog model. The model proved predictive and close agreement was observed with the experimentally observed data.