Brain neurotransmitter abnormalities in neuronal intranuclear inclusion body disorder

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Abstract
Biochemical markers for the major neurotransmitter systems measured in the brain of a patients who died with neuronal intranuclear inclusion disease. A severe nigrostriatal dopamine deficiency constitutes the basis for the parkinsonian features in the patient. A marked loss of brain norepinephrine and serotonin was found in basal ganglia and hypothalamus. Brain amino acid (γ‐aminobutyric acid and glutamate) and cholinergic (choline acetyltransferase activity) systems were either normal or less severely affected.