Immunological consequences of intestinal helminth infections. Humoral responses to ovalbumin

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Abstract
Summary Humoral responses to ovalbumin (OA) administered i.p. with Al(OH)3‐were depressed in C57BL mice immunized 5–13 days after infection with N. dubius, but not N. brasiliensis or T. muris. These two parasites induced elevated IgM responses, possibly as a result of systemic contact with parasite larvae or debris since i.v. administered N. dubius also increased IgM titres to OA. Depression of anti‐OA IgG titres by N. dubius was also observed in infected BALB/c and CBA mice given OA‐Al(OH)3 (i.p.), but not in C57BL mice given OA‐Al(OH)3 (s.c), OA‐FCA (i.p. or s.c), or OA‐B. pertussis (i.p.). These findings suggest that local effects of N. dubius within the peritoneum reduce the adjuvanticity of Al(OH)3, resulting in depressed responses to OA‐Al(OH)3.