Antileukemic activity of ungeremine and related compounds. Preparation of analogs of ungeremine by a practical photochemical reaction
- 1 February 1978
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (2) , 199-203
- https://doi.org/10.1021/jm00200a011
Abstract
A number of alkoxypyrrolophenanthridinium salts and their analogues related to the antileukemic alkaloid ungeremine were prepared by a practical photochemical cyclization. The importance of the quaternary nitrogen atom and of alkoxy groups, the planarity of a molecule, and steric considerations relative to antileukemic activity are discussed.Keywords
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