Synovial Sarcoma With a Predominant Epithelial Component

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Abstract
A case of synovial sarcoma of the lower leg in a 59-year-old woman with a predomi nant epithelial component is reported. Histologically, the tumor showed a well-devel oped epithelial component with a sheet-like and cribriform pattern with a sparsely distributed spindle cell component. Immunohistochemically, the epithelial component was positive for cytokeratins and epithelial membrane antigen, while the spindle cell component was positive for cytokeratins, epithelial membrane antigen, and vimentin. The epithelial component of synovial sarcoma is indistinguishable from carcinoma morphologically and immunohistochemically, therefore the presence of a biphasic pattern, even with a paucity of spindle cell component, is a crucial finding to establish a diagnosis of synovial sarcoma. The recognition and subclassification of this type of synovial sarcoma is important in arriving at a correct prognosis. Int J Surg Pathol 1(4): 261-268, 1994

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