Efficacy of ribavirin plus interferon‐α in patients aged ≥60 years with chronic hepatitis C

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Abstract
In Japan, patients with hepatitis C virus (HCV)-associated liver disease are getting older, and thus the number of deaths due to such disease is increasing. The efficacy of combination therapy with ribavirin and interferon for chronic HCV infection in elderly patients has not been fully clarified. The aim of the present study was to evaluate the efficacy and tolerability of combination therapy in such patients. Two hundred and twenty consecutive patients with chronic hepatitis C were treated with combination therapy. These patients were divided into two groups according to age: patients >or= 60 years (n = 66) and patients < 60 years (n = 154). Clinical characteristics, the sustained virologic response (SVR) rate obtained by intention-to-treat analysis, and the rate of reduction or discontinuation of ribavirin were compared between the two groups. The ribavirin discontinuation rate was significantly higher in the patients aged >or=60 years than in the patients aged or=60 years and those aged or=60 years and those aged <60 years, although the ribavirin discontinuation rate was higher among the older patients than the younger patients.

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