THE ANTI-MYCOTIC ACTIVITY INVITRO OF 5 DIOLS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 18  (4) , 287-293
Abstract
The antimycotic activity of ethane-1,2-diol, propane-1,2-diol, butane-1,3-diol, pentane-1,5-diol and hexane-2,5-diol in vitro against Pityrosporum orbiculare, Candida albicans, Trichophyton rubrum, T. mentagrophytes var. interdigitale and Epidermophyton floccosum was studied. Ethane-1,2-diol had the lowest activity (MIC [minimum inhibitory concentration] of 40-100 g l-1), and hexane-2,5-diol the highest activity (MIC of 10-40 g l-1). Among the higher diols there can be both effective antifungal agents and substances with a lower risk of allergic and irritative skin reactions than propane-1,2-diol.

This publication has 1 reference indexed in Scilit: