A note on the esterification of α‐D‐glucopyranosyl phosphate with benzyl halides

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Abstract
Esterification of the bis(tetrabutylammonium) salt of α‐D‐glucopyranosyl phosphate (1) with benzyl chloride or bromide in acetonitrile gave α‐D‐glucopyranosyl benzyl phosphate (2) in 80‐90% yield. An excess of benzyl chloride catalysed further reaction to a mixture of six phosphoric acid diesters via phosphoric acid triesters and D‐glucopyranosyl chlorides as intermediates. 1‐Bromohexane gave α‐d‐glucopyranosyl hexyl phosphate by the same method.