In the majority of instances, the focal atrophy in Pick's disease is that of a combined frontotemporal or frontotemporoparietal type. Because of such widespread lesions it has been difficult to correlate the individual symptoms with any anatomic localization, and it would appear more suitable to analyze cases in which there is selective involvement of either the frontal or the temporal area. Cases in which there is exclusive, or predominant, atrophy of the temporal lobes are comparatively rare. It is the purpose of this report to analyze such a case and attempt a clinical and pathoanatomic correlation. REPORT OF A CASE History. —A. C., a white housewife aged 59, married, was admitted to the hospital on March 14, 1933, because of personality change and loss of memory. The family history was characterized by numerous instances of alcoholism and personality disorder and by the occurrence of a psychosis described as "religious mania"