Mutagenic Effect of Azaserine in Relation to Azaserine Resistance in Escherichia coli

27 March 1959

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 129 (3352) , 839-840
https://doi.org/10.1126/science.129.3352.839

Abstract

For demonstration of the mutagenic effect of azaserine (mutation from streptomycin dependence to nondependence), higher concentrations of this antibiotic are required with azaserine-resistant Escherichia coli than with the sensitive, parental strain. At barely toxic concentrations of azaserine, however, the mutagenic response of the resistant strain is many times higher than that of the sensitive strain.

Keywords

CYTOTOXIC DRUGS/EFFECTS
ESCHERICHIA COLI/EFFECT OF DRUGS ON
SERINE/RELATED COMPOUNDS

This publication has 1 reference indexed in Scilit:

THE MECHANISM OF CHEMICAL MUTAGENESIS. I. KINETIC STUDIES ON THE ACTION OF TRIETHYLENE MELAMINE (TEM) AND AZASERINE
Proceedings of the National Academy of Sciences, 1958