Studies on Anti-inflammatory Agents. XXXIX. Effect of 2-(5H-[1]Benzopyrano-[2, 3-b]pyridin-7-yl)propionic Acid (Y-8004) on Leucocyte Emigration and Enzyme Release from Emigrated Leucocytes in Vivo

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Abstract
In carrageenan-induced peritonitis in rats, 2-(5H[1]benzopyrano[2,3-b]pyridin-7-yl)-propionic acid (Y-8004) given orally significantly inhibited protein exudation and leukocyte accumulation. This agent also accelerated the absorption of peritoneal fluids in prophylactic experiments, and the decrease of peritoneal fluids, exudative protein and leukocyte counts in therapeutic experiments. The free activity and ratio of lysosomal enzymes such as aryl sulfatase increased markedly in the peritoneal fluids of rats with carrageenan plus zymosan-induced peritonitis. The increment may be due to the release of zymosan from migrated leukocytes during phagocytosis. Y-8004 not only inhibited the increment but also showed the same effect on the above indexes in therapeutic experiments. These effects were also observed in the oral treatment with indomethacin, phenylbutazone or ibuprofen. Y-8004 and the anti-inflammatory agents used have an inhibitory activity on the release of lysosomal contents in vivo.