T-cell receptor genes in autoimmune mice: T-cell subsets have unexpected T-cell receptor gene programs.
Open Access
- 1 August 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (16) , 5883-5887
- https://doi.org/10.1073/pnas.84.16.5883
Abstract
Two unique cell subsets have been identified in the autoimmune-prone MRL/MP lpr/lpr and C3H/HeJ gld/gld murine strains that have the Lyt-2-, L3T4-, Thy-1+, and Lyt-2-, L3T4-, Ia-, Thy-1- phenotypes, respectively. We have now found that these cells express T-cell receptor proteins on their surface. Our observations further indicate that the expression of the Thy-1 antigen does not correlate with the expression of .alpha.-chain and .beta.-chain T-cell receptor polypeptides. Interestingly, T-cell receptor .gamma.-chain RNA expression may be influenced or correlate with Thy-1 molecular expression. These studies indicate unusual relationships of different cell-surface structures that may reflect unexpected developmental programs.Keywords
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