COMPLICATIONS WITH THE USE OF A PARASYMPATHETIC-STIMULATING DRUG

7 January 1950

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 142 (1) , 12-15
https://doi.org/10.1001/jama.1950.02910190014003

Abstract

The parasympathetic-stimulating drugs are important adjuncts in the treatment of atonic and hypotonic bladders. The clinical toxicity, precautions and contraindications in their use have been well documented.¹During the use of one of these drugs, furmethide® (furfuryl trimethylammonium iodide),²in the cases to be cited from the practice of one of us (C. N.), a complication developed which, to our knowledge, has not been previously reported. Acute pyelonephritis developed during effective therapeutic dosage of furmethide® in 2 patients, both of whom had a large amount of residual urine and vesicoureteral reflux. REPORT OF CASES Case 1.— S. J., a 3 year old white girl, was first observed on Sept. 23, 1946. The child had been delivered at the eighth month of gestation, weighing 5 pounds 7 ounces (2,466 Gm.). The obstetrician noted that the infant had a spina bifida with meningocele. When she was 3 weeks of age

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