GM ALLOTYPES IN MYASTHENIA-GRAVIS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 1  (8170) , 677-680
Abstract
Gm typing and acetylcholine receptor antibody assay were performed on serum samples from 74 patients with myasthenia gravis (31 male, 43 female) and from 236 unrelated normal blood-donors. The haplotype Gm1,2,21 was significantly more common in patients with myasthenia gravis (relative risk = 3.24), especially those with thymoma (relative risk = 6.99). The frequency of haplotype Gm1,2,21 was further increased in patients with severe generalized myasthenia gravis (relative risk = 10.52). The frequency of Gm1,2,21 was also increased in patients with high acetylcholine receptor antibody titers (> 5 pmol/ml). The presence of a pathogenic gene close to the Ig[immunoglobulin]G H-chain gene complex in the 6th chromosome in the patients with myasthenia gravis, especially those with thymoma, is indicated.

This publication has 0 references indexed in Scilit: