A man with presumptive Y/Y translocation, observed in a forensic psychiatric department

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Abstract
A man charged with a sexual offence had a complex karyotype anomaly, including a Y-chromosome of aberrant structure. Other features were very small stature, skeletal deformities and obscure neurological defects. There were no gross psychiatric symptoms, nor was there mental retardation. Q and G-banding and photometric scanning of the chromosomes of the propositus and his 3 healthy brothers indicated that the aberrant Y-chromosome probably arose from a reciprocal translocation, which may be written: t(Y:Y) (qter .fwdarw. p11: :q11 .fwdarw. qter). Fibroblast cultures differed from the lymphocytes; in the former the majority of the cells lacked the abnormal Y-chromosome, their karyotype being 45,XO.