Inhibitory Effect of Dietary Wheat Bran on Formation of Aberrant Crypt Foci in Rat Colon Induced by a Single Injection of 1,2-Dimethylhydrazine
- 1 January 1996
- journal article
- Published by Taylor & Francis in Bioscience, Biotechnology, and Biochemistry
- Vol. 60 (12) , 2084-2085
- https://doi.org/10.1271/bbb.60.2084
Abstract
The frequency of appearance of aberrant crypt foci (ACF) in the distal colon was significantly lower in rats fed a high fiber (20% wheat bran) diet than in those fed a fiber-free one at 4 weeks after a single injection of 1,2-dimethylhydrazine (DMH, 20 mg/kg), although crypt/ACF was high in the former relative to the latter. This result suggests that dietary wheat bran effectively serves as a regulator of ACF frequency at early stages after DMH injection.Keywords
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