Alpha 1 Antitrypsin in the Livers of Patients with Emphysema
- 7 January 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4017) , 63-65
- https://doi.org/10.1126/science.175.4017.63
Abstract
Parenchymal liver cells from emphysema patients with an inherited deficiency of α1-antitrypsin contain globules of glycoprotein that bind fluorescent antibody to α1-antitrypsin. The globules can be seen after hematoxylin and eosinstaining or on electron microscopy, but are more readily demonstrated by PAS stain of amylase-treated liver sections. It appears that an inappropriately large amount of α1-antitrypsin is found in the liver even when there is a deficiency in the serum. Genetic variants of the normal antitrypsin molecule may be unable to leave their site of synthesis in the liver cell because of some molecular aberration.Keywords
This publication has 4 references indexed in Scilit:
- Screening for Heterozygous α1-Antitrypsin DeficiencyPublished by American Medical Association (AMA) ,1971
- Alpha-1-antitrypsin deficiency and its effect on the liverHuman Pathology, 1971
- Heterozygous and Homozygous Alpha1-Antitrypsin Deficiency in Patients with Pulmonary EmphysemaNew England Journal of Medicine, 1969
- SITES OF FORMATION OF IMMUNE GLOBULINS AND OF A COMPONENT OF C'3The Journal of Experimental Medicine, 1961