Effect of Streptomycin Aerosol on Friedlander's Pneumonia in Rats.
- 1 May 1948
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 68 (1) , 210-212
- https://doi.org/10.3181/00379727-68-16435
Abstract
Comparative effectiveness of parenteral and inhalational adm. of streptomycin in prevention of Friedlander''s pneumonia was detd. in rats previously inoculated intrabronchially with fatal doses of Friedlander''s bacillus. Of 10 rats infected with 100,000 MLD and treated by intramus. injn. of 1,000 micrograms of streptomycin 4 times a day for 3 days, all survived, while 10 untreated rats died. When similar amts. of streptomycin aerosol were given at the same intervals to 30 rats infected with from 30,000 to 100,000 MLD, 60 to 70% survived. All of the 30 control rats died. When the infective dose was reduced to 17,000 MLD, all of 10 rats survived after receiving an estimated inhalational dose of 2,200 micrograms of streptomycin 4 times a day for 4 days, while 8 of 10 untreated rats died.Keywords
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