IMMUNOHISTOCHEMICAL LOCALIZATION OF THE MOUSE STAGE-SPECIFIC EMBRYONIC ANTIGEN-1 IN HUMAN-TISSUES AND TUMORS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (2) , 669-678
Abstract
Normal human tissues and various human tumors were surveyed by immunohistochemical techniques for expression of the stage-specific embryonic antigen 1 (SSEA-1). The antibody reacted with many normal and neopastic human tissues. In most instances, equivalent human and mouse tissues expressed SSEA-1; however, different tissue localization patterns were sometimes seen between these 2 species. Most SSEA-1-positive tumors originate from tissues that normally expressed this antigen [i.e., certain hemopoietic or lymphoid tissues, nervous system, urinary tract, and some gastrointestinal tissues]; however, some breast and ovarian tumors are SSEA-1 positive, and these organs are SSEA-1 negative. SSEA-1-positive tumors were composed of both immunoreactive and nonreactive tumor cells. SSEA-1, initially defined as a mouse embryonic antigen, represents a heterogenetic antigen present in many normal human tissues. It is retained on many but not all neoplastic cells originating in these normal tissues and also appears on the surface of some tumor cells developing in SSEA-1-negative tissues.

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