REDUCTION OF BLOOD PRESSURE ASSOCIATED WITH THE PYROGENIC REACTION IN HYPERTENSIVE SUBJECTS 1

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Abstract
Blood pressure was reduced significantly in hypertensive subjects by the intraven. adm. of pyrogenic material (pyrogenic inulin, triple typhoid vaccine, tyrosinase), and it was maintained at reduced levels by the repeated injs. of this material. This hypotensive effect was obtained without a rise in body temp. by premedication with amido-pyrine. The mechanism responsible for the persistent blood pressure reduction was unknown, but, from the more immediate effects of pyrogen, it was attributable in part to an adverse or asthenic action on the cardiovascular system, rather than a correction of the fundamental disturbance underlying the hypertensive process. One instance of a marked reduction in blood pressure in a hypertensive subject during a post-cytoscopic febrile reaction was illustrated. Such reactions were attributable to a transient B. coli bacteremia, and the reduction of blood pressure here, and in other acute infections, might be associated with the pyrogenic reaction associated with the infection. Whenever the blood pressure of a hypertensive subject is reduced by the parenteral adm. of a foreign organic material, this pyrogenic type of response should be excluded, before a specific hypotensive property is attributed to the agent used. And any pyrogenic material should be administered cautiously, since it might induce an alarming degree of peripheral circulatory failure.

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