Isoniazid Alone Compared with Isoniazid and PAS in the Treatment of Minimal and Noncavitary, Moderately Advanced, Previously Untreated Pulmonary Tuberculosis1,2

1 March 1963

journal article
research article
Published by American Thoracic Society in American Review of Respiratory Disease

Vol. 87 (3P1) , 424-428
https://doi.org/10.1164/arrd.1963.87.3p1.424

Abstract

Regimen of isoniazid alone (300 mg daily) in patients with minimal and noncavitary moderately advanced tuberculosis was definitely inferior to that of isoniazid and p-amino salicylic acid. Both regimens are extremely effective; however, difficulties due to PAS toxicity were sufficiently frequent to negate its beneficial therapeutic effect. Use of isoniazid as a single drug is still considered to be effective therapy under circumstances which make addition of PAS undesirable.