The epithelium of the excretory duct of the human submandibular gland: A transmission and scanning electron microscopic study

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Abstract
The duct of the human submandibular gland (Wharton) is lined by a pseudostratified epithelium consisting of principal and basal cells. Scattered among them are a few goblet and ciliated cells.The principal cells are columnar in shape with many mitochondria, numerous dense bodies and a central nucleus with some indentations. Their apical cytoplasm shows a number of clear vesicles, some of which are reactive to silver and are extruded by exocytosis into the lumen. Other vesicles, which are unreactive, may represent the products of the absorption process. A mechanism of apocrine secretion is also observed in the principal cells.Thus, with regard to its functions, the duct of the human submandibular gland modifies the composition of saliva by adding a secretory component to it. This latter material is derived from the goblet cells but chiefly from merocrine (exocytosis) and apocrine secretion of principal cells.