Optimized Relaxivity and Stability of [Gd(H(2,2)-1,2-HOPO)(H2O)]- for Use as an MRI Contrast Agent1
- 11 May 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Inorganic Chemistry
- Vol. 46 (12) , 4796-4798
- https://doi.org/10.1021/ic700399p
Abstract
Relaxometry and solution thermodynamic measurements show that Gd(H(2,2)-1,2-HOPO) is a good candidate as a contrast agent for magnetic resonance imaging (MRI-CA). Acidic, octadentate H(2,2)-1,2-HOPO forms a very stable Gd(III) complex [pGd = 21.2(2)]. The coordination sphere at the Gd(III) center is completed by one water molecule that is not replaced by common physiological anions. In addition, this ligand is highly selective for Gd(III) binding in the presence of Zn(II) or Ca(II). The symmetric charge distribution of the 1,2-HOPO chelates is associated with favorably long electronic relaxation time T1,2e comparable to those of GdDOTA. This, in addition to the fast water exchange rate typical of HOPO chelates, improves the relaxivity to r1p = 8.2 mM-1 s-1 (0.47 T). This remarkably high value is unprecedented for small-molecule, q = 1 MRI-CA.Keywords
This publication has 14 references indexed in Scilit:
- 1,2-Hydroxypyridonates as Contrast Agents for Magnetic Resonance Imaging: TREN-1,2-HOPOInorganic Chemistry, 2007
- An Octadentate Luminescent Eu(III) 1,2-HOPO Chelate with Potent Aqueous StabilityInorganic Chemistry, 2007
- Optimized Relaxivity and Stability of [Gd(H(2,2)-1,2-HOPO)(H2O)]- for Use as an MRI Contrast Agent1Inorganic Chemistry, 2007
- Substituent Effects on Gd(III)-Based MRI Contrast Agents: Optimizing the Stability and Selectivity of the Complex and the Number of Coordinated Water Molecules1Inorganic Chemistry, 2006
- Strategies for increasing the sensitivity of gadolinium based MRI contrast agentsChemical Society Reviews, 2006
- Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agentsContrast Media & Molecular Imaging, 2006
- Next Generation, High Relaxivity Gadolinium MRI AgentsBioconjugate Chemistry, 2004
- Gadolinium(III) 1,2-Hydroxypyridonate-Based Complexes: Toward MRI Contrast Agents of High Relaxivity1Inorganic Chemistry, 2004
- Toward Optimized High-Relaxivity MRI Agents: The Effect of Ligand Basicity on the Thermodynamic Stability of Hexadentate Hydroxypyridonate/Catecholate Gadolinium(III) ComplexesInorganic Chemistry, 2003
- Structural and Dynamic Parameters Obtained from 17O NMR, EPR, and NMRD Studies of Monomeric and Dimeric Gd3+ Complexes of Interest in Magnetic Resonance Imaging: An Integrated and Theoretically Self-Consistent Approach1Journal of the American Chemical Society, 1996