Chronological Changes of Electrocochleogram in Experimental Endolymphatic Hydrops

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Abstract
Chronological changes of the whole nerve action potential (AP), cochlear microphonics (CM) and summating potential (SP) in experimental endolymphatic hydrops in guinea pigs were studied during a 1 wk-13 mo. period after endolymphatic sac obliteration. Endolymphatic hydrops became extensive after 3 mo. and persisted thereafter. The threshold of AP increased with the lapse of time but good AP output potential was obtained, being maximum after 3 mo. The threshold of CM increased with the lapse of time. The CM output potential was the highest around the 3rd wk when endolymphatic hydrops was slightly formed, and it decreased thereafter. SP response at the frequencies of 8, 4, 1 and 0.5 kHz showed the reversed polarity of -SP after 3 mo., and changed towards potential 0 thereafter. In animals showing supernormal AP output potential, the cilia in the 3rd row of outer hair cells were disarranged. This seems to be involved in recruitment.

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