Antisense Oligonucleotides with Alternating Phosphodiester-"Amide-3" Linkages
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (02) , 137-140
- https://doi.org/10.1055/s-1994-22769
Abstract
The synthesis of the building blocks required for the preparation of all the "amide-3" dimers is reported. Five representative dimers are described, as well as the melting temperatures (Tm) of the duplexes formed between an oligonucleotide containing alternating phosphodiester-"amide-3" linkages with its complementary DNA and RNA strand.Keywords
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