Short-Term Effect of Oophorectomy on Lipoprotein Metabolism

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Abstract
The influence of steroid hormones on lipoprotein metabolism was investigated in menstruating women undergoing oophorectomy; indeed, by this procedure, it is possible to alter selectively the secretion of the hormones and thus to determine the influence of their withdrawal on blood lipids. Within 3 mo. of surgery significant rapid changes in cholesterol levels of total and HDL[high density lipoprotein]-bound components (early decrease and subsequent increase) without alteration of the triglyceride component of the lipoproteins was observed. Similar biphasic changes were observed for the apolipoproteins A and B, determined by immunological methods. Sex hormones may act on lipoprotein metabolism, both on the lipid and the protein moieties. They can be explained by a primary action of the hormones on the apolipoprotein metabolism and a secondary apoprotein-mediated effect on the lipid component of the lipoproteins.
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