Effect of 2-mercaptoethanol on the haemagglutinating activity and antigenic properties of rubella virus

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Abstract
Tween-ether treated rubella virus extract treated with 2-mercaptoethanol no longer haemagglutinates and its ability to combine with antibody is reduced although its sedimentation characteristics and the electrophoretic mobilities of the envelope glycoproteins are unaffected. The role of disulphide bonds in maintaining the structural and functional integrity of rubella virus is discussed.