Transient Pure Red-Cell Aplasia: Cell-Mediated Suppression of Erythropoiesis Associated with Hepatitis

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Abstract
Transient pure red-cell aplasia is a rare complication of persistent acute hepatitis. Possible mechanisms for marrow suppression in 1 patient who developed erythroid aplasia in the course of transfusion-related hepatitis was investigated. The patient''s lymphocytes, obtained during the acute illness, markedly inhibited erythroid colony formation by donor marrow. After the patient recovered, remission lymphocytes in co-culture did not inhibit colony formation. No reversible suppression was demonstrable by addition of patient serum. Hematocytopenias associated with hepatitis may result from cell-mediated suppression induced by hepatic injury.