Functional characteristics ofl-glutamate,N-methyl-d-aspartate and kainate receptors in isolated brain synaptic membranes
- 1 July 1984
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 9 (7) , 903-915
- https://doi.org/10.1007/bf00964522
Abstract
L-Glutamic acid (l-Glu) and other excitatory amino acids and amino acid analogs enhanced [35S]thiocyanate (SCN−) uptake in isolated-resealed synaptic membrane vesicles. The SCN− uptake was used as a measure of membrane depolarization to evaluate the characteristics of functional excitatory amino acid receptors in the synaptic membranes.N-Methyl-d-aspartate (NMDA) andl-Glu produced additive effects on SCN− accumulation indicating the presence of distinctl-Glu and NMDA receptors. On the other hand, kainic acid (KA) andl-Glu shared either common receptor sites or ion channels. The effects of antagonists on NMDA,l-Glu, and KA stimulation of SCN− influx were consistent with previously reported electrophysiologic observations in intact neurons.This publication has 24 references indexed in Scilit:
- Purification, Biochemical Characterization, Binding Activity, and Selectivity of a Glutamate Binding Protein from Bovine BrainJournal of Neurochemistry, 1984
- Purification and Molecular Characterization of the Brain Synaptic Membrane Glutamate-Binding ProteinJournal of Neurochemistry, 1983
- Antagonists of synaptic and amino acid excitation of neurones in the cat spinal cordBrain Research, 1983
- l-Glutamate effects on electrical potentials of synaptic plasma membrane vesiclesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1982
- Excitatory Amino Acid TransmittersAnnual Review of Pharmacology and Toxicology, 1981
- Molecular characteristics of glutamate receptors in the mammalian brainMolecular and Cellular Biochemistry, 1981
- Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations.The Journal of Physiology, 1980
- Selective antagonism of amino acid‐induced and synaptic excitation in the cat spinal cord.The Journal of Physiology, 1979
- The glutamate receptor-like protein of brain synaptic membranes is a metalloproteinBiochemical and Biophysical Research Communications, 1979
- Crayfish Muscle Fiber: Ionic Requirements for Depolarizing Synaptic ElectrogenesisScience, 1967