Solid phase synthesis of mono- and di-saccharide-containing glycopeptides
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 17,p. 1267-1268
- https://doi.org/10.1039/c39890001267
Abstract
Derivatives of Fmoc-threonine (Fmoc = fluoren-9-ylmethoxycarbonyl) with O-glycosidically peracetylated β-D-Galp-(1 → 3)-α-D-GalNAcp or α-D-GalNAcp chains have been used in a solid phase synthesis of the oncofetal fibronectin sequence VTHPGY (benzyl protection was used on histidine and tyrosine); a super-acid sensitive resin was used, which enabled the isolation of the protected glycopeptide after synthesis, a feature that substantially facilitated verification of the structure by n.m.r. and m.s.Keywords
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