Prognosis and adjuvant treatment effects in selected breast cancer subtypes of very young women (<35 years) with operable breast cancer
Open Access
- 23 March 2010
- journal article
- research article
- Published by Elsevier in Annals of Oncology
- Vol. 21 (10) , 1974-1981
- https://doi.org/10.1093/annonc/mdq072
Abstract
Background: There is limited knowledge about prognosis of selected breast cancer subtypes among very young women. Patients and methods: We explored patterns of recurrence by age according to four immunohistochemically defined tumor subtypes: Luminal A and Luminal B (estrogen receptor positive and/or progesterone receptor positive and either human epidermal growth factor receptor 2 (HER2) positive and/or high Ki-67), HER2-positive (and) endocrine receptor absent and Triple Negative, in 2970 premenopausal patients with pT1-3, pN0-3 and M0 breast cancer. Results: Patients Conclusions: Very young patients with Triple Negative, Luminal B or HER2-positive breast cancer have a worse prognosis when compared with older patients with similar characteristics of disease.Keywords
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