High mobility group proteins 1 and 2 bind preferentially to brominated poly(dG‐dC)·poly(dG‐dC) in the Z‐DNA conformation but not to other types of Z‐DNA

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Abstract
Three proteins from bull testis, previously thought to be Z‐DNA‐binding proteins but recently found to recognize brominated poly(dG‐dC)·poly(dG‐dC) by criteria different from the Z‐conformation, were partially sequenced. Of these, the 31 kDa protein was identified as a member of the high mobility group 2 protein family, and the 33 kDa protein as a member of the high mobility group 1 protein family. Both proteins had molecular weights approximately 30% higher than expected, indicating considerable posttranslational modification. In contrast, the 58 kDa protein remained unidentified for lack of any significant homology with known protein sequences.