Changes in liver drug glucuronidation during cholestasis are non predictable
- 1 January 1994
- journal article
- research article
- Published by Taylor & Francis in Archives Internationales de Physiologie, de Biochimie et de Biophysique
- Vol. 102 (2) , 121-123
- https://doi.org/10.3109/13813459408996118
Abstract
Liver microsomal glucuronidation of acetaminophen, chloramphenicol, salicylic acid, lorazepam, p-nitrophenol and morphine were measured in 8 days bile duct ligated rats. Compared to normals, cholestatic rats showed a decrease of 31% for p-nitrophenol glucuronidation; salicylic acid glucuronidation increased 281%; acetaminophen glucuronidation increased 38% while morphine, chloramphenicol and lorazepam values were similar to controls. We concluded that cholestasis produces non predictable changes on liver drug glucuronidation pathways.Keywords
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