Incidence and mechanism of neutropenia and thrombocytopenia in patients with human immunodeficiency virus infection

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Abstract
The incidence of lymphopenia, thrombocytopenia and neutropenia was studied in 105 homosexual men with HIV infection. Lymphopenia was common in patients with AIDS (75%), but its incidence in PGL (24%) was not significantly different from that in asymptomatic anti-HIV positive (15%) homosexual men. Neutropenia and thrombocytopenia were found in patients with AIDS or PGL. but not in asymptomatic anti-HIV positive homosexuals. The study suggests that the neutropenia and thombocytopenia in these patients were due to autoimmune destruction of neutrophils and platelets.