Rat Brain Capillary Endothelial Cells Express Functional PDGF B-Type Receptors
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Growth Factors
- Vol. 2 (1) , 1-8
- https://doi.org/10.3109/08977198909069076
Abstract
Immunohistochemical staining revealed the presence of platelet-derived growth factor (PDGF) B-type receptors on capillaries of normal rat brain. Furthermore, capillary endothelial cells isolated from rat brain and grown in tissue culture bound [125I)PDGF-BB but not [125I]PDGF-AA, suggesting that they expressed B-type, but not A-type, PDGF receptors. PDGF-BB and PDGF-AB, but not PDGF-AA, also stimulated incorporation of [3H]thymidine into these cells. Thus, rat brain capillary endothelial cells have functional B-type receptors, and thereby differ from endothelial cells derived from large blood vessels, that do not express PDGF receptors. Our data suggest a possible role for PDGF-BB as an angiogenic factor.Keywords
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