Congenital Deficiency of Cyclo-Oxygenase in a Woman with Generalized Atherosclerosis

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Abstract
The case of a 52-yr-old woman with congenital cyclooxygenase deficiency, signs of generalized atherosclerosis and a moderate bleeding tendency is reported. Secondary platelet aggregation was absent. Platelet aggregation induced by arachidonic acid failed totally; that induced by Ca ionophore was normal. No malondialdehyde formation could be detected in her platelet-rich plasma. The life-long deficiency of cyclooxygenase had not protected her from progressive vascular disease. The chronic intake of large doses of aspirin apparently cannot prevent arterial disorders.