Rapid Induction of Prolactin Secretion by 3-Iodo-L-Tyrosine

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Abstract
This study was aimed at determining whether 3-iodo-L-tyrosine (mono-iodotyrosine, MIT), a potent but short-lived inhibitor of tyrosine hydroxylase, is able to release prolactin secretion from dopamine inhibition. Administration of MIT (100 mg/kg, i.p.) to normal rats caused a highly significant elevation of serum prolactin levels within 30 min. This rise was not due to the initial metabolites of MIT. The properties of MIT suggest its use in clinical studies of prolactin secretion.

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