An Antipruritic Agent for Primary Biliary Cirrhosis and Cholestatic Jaundice

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Abstract
Cholestyramine resin binds cholates in the intestine, thus preventing their reabsorption and thereby lowering the blood cholate levels. This action leads to relief of the pruritus occurring in primary biliary cirrhosis and cholestatic jaundice. Preventing the reabsorption of cholates also causes an increase in their synthesis from cholesterol, which, in turn, usually results in at least a temporary reduction in blood cholesterol. The drug currently is under investigation for its cholesteropenic effects.

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