Left Ventricular Mass Index and Diastolic Filling

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Abstract
The relationships of left ventricular (LV) structure and diastolic filling to ambulatory blood pressure, race, age, and gender were studied in 104 young, generally healthy, untreated subjects with normal or marginally elevated blood pressure. Average daytime systolic blood pressure (r = 0.41, P < .001), diastolic blood pressure (r = 0.38, P < .001), male gender (r = 0.49, P < .001), and age (r = 0.32, P < .001) were univariate correlates of LV mass index as measured by M-mode echocardiography. In a stepwise multiple regression model, male gender, age, and systolic blood pressure were independent predictors of LV mass index. LV filling rate normalized to mitral stroke volume, a Doppler-derived index of diastolic filling, was inversely related to age (r = − 0.47, P < .001), heart rate (r = − 0.27 , P < .01), LV mass index (r = − 0.32 , P < .001), and diastolic blood pressure (r = −0.20, P < .05). Age, heart rate, and LV mass index were predictors of normalized peak filling in a stepwise regression model. Race was not significantly related to either LV mass index or diastolic filling. Our results confirm the importance of demographic variables as well as blood pressure in determining LV mass and filling characteristics in humans prior to the development of sustained essential hypertension. These variables contribute to ventricular mass and diastolic function in varying degrees. Gender is strongly correlated with LV mass, but not with filling indices. Age is an important determinant of diastolic performance, and influences ventricular mass to a significant but lesser extent. Blood pressure is an independent determinant of LV mass. The relationship of blood pressure to diastolic filling, however, may be mediated by its influence on LV mass. Am J Hypertens 1991;4:579–585.

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