BINDING OF SYNTHETIC ANABOLIC STEROIDS TO TESTOSTERONE-ESTRADIOL BINDING GLOBULIN AND TO RAT PROSTATE CYTOSOL

  • 1 January 1977
    • journal article
    • research article
    • Vol. 11  (2) , 85-90
Abstract
The binding of 5 synthetic anabolic steroids and 2 natural androgens to testosterone-estradiol binding globulin (TeBG) and to cytoplasmic fraction containing androgen receptors from prostates of castrated rats was compared. The binding affinity to TeBG decreased in sequence: dihydrotestosterone, testosterone, methyltestosterone, methandienone, nortestosterone, dimethylandrostanolone, nortestosterone phenylpropionate (no binding); in the prostatic cytosol the following decreasing sequence was found: dihydrostestosterone, methyltestosterone, methandienone, nortestosterone, nortestosterone phenylpropionate, testosterone, dimethylandrostanolone. The low binding to TeBG of 17.alpha.-methylated steroids possessing at the same time high affinity to cytoplasmic receptors may enhance their effect in target tissues.

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